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Document 2491
DOCN M94A2491
TI Factors influencing cytomegalovirus infection among HIV+ patients with
known date of infection. SEROCO Study Group.
DT 9412
AU Carre N; Deveau C; Persoz A; Rouzioux C; Colasante U; Salmon-Ceron D;
Bucquet D; INSERM U292, Paris, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):292 (abstract no. PC0094). Unique
Identifier : AIDSLINE ICA10/94370084
AB OBJECTIVE: To assess factors influencing the prevalence and incidence of
CMV infection through a French cohort (SEROCO) of non hemophiliac
HIV-infected adult patients with known date of HIV-infection. METHODS:
The date of HIV infection was the mid-point of a maximum two years
interval between HIV-/HIV+ serology, or the date of a well documented
HIV primary infection (n = 545). Prevalence of CMV infection was defined
by the presence of CMV IgG antibody (ELISA) at first visit, and CMV
incidence by the seroconversion to CMV at a biannual visit among
initially negative patients (n = 83). Influence of covariates related to
sexual behavior on prevalence and incidence of CMV infection were
assessed by a logistic regression and a Cox model. RESULTS: TABULAR
DATA, SEE ABSTRACT VOLUME. No association was shown with sexually
transmitted disease (std)(p = 0.1) and sex (p = 0.4). Incidence of CMV
seroconversion (17/83), after a mean of follow-up of 33 months, was 8.6
per 100 person-years (py). After taking into account age, occurrence of
a std, sex with at least a casual partner, high risk behaviour, the only
predictive variable of CMV seroconversion was homosexual behavior [R.R =
2.9, p < 0.05] relative to heterosexual behavior. CONCLUSION:
HIV-infected patients engaged in homosexual practices have an increased
risk of CMV seroconversion relative to those engaged in heterosexual
practices independently of occurrence of std, having sex with at least a
casual partner or having a high risk behaviour.
DE Adult AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY Blood
Transfusion Cytomegalovirus Infections/*COMPLICATIONS/EPIDEMIOLOGY
France/EPIDEMIOLOGY Human Incidence Prevalence Risk Factors Sex
Behavior Substance Abuse, Intravenous/COMPLICATIONS Time Factors
MEETING ABSTRACT MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).